Sunday, October 18, 2020

taurine is something that i'm sort of afraid of due to it's testosteronic effects, and i've avoided energy drinks for years because of it. the flip side of taurine is that it's a neurotransmitter that some studies suggest that we may not be able to generate in sufficient amounts (although we can generate some of it), and it is for that reason that i'm interested in it. 

taurine is plentiful in meat and scarce in plants, but it's also scarce in eggs & dairy, and is not fortified at all, which makes it a particular problem for me - the only source of this is actual flesh, and there's not really any way around it. well, besides drinking red bull or popping pills.

as mentioned, your body can create it. what's unclear is if your body creates enough. so, there is no rdi for taurine, but it is sometimes listed with the b vitamins and there is some thinking that one ought to be established.

that's what i need to figure out, with this - within some reasonable limits.

so, what happens when you consume taurine in your diet?

In 40 studies carried out in 16 normal adult males the 24 hour urine taurine excretion was found to lie between 58 and 208 mg. with occasional variations in the same individuals of as much as 80 per cent. The rate of excretion was not found to be appreciably influenced by the intake of fluid. In multiple studies in three normal men high calorie, high protein diets were found to increase the output of taurine an average of 24 per cent. Low protein diets had the opposite effect.

so, it seems like we largely excrete dietary taurine when we get it - and, it would seem, even when we're low on it. so, if you give a vegan a burger, she's mostly just going to piss the taurine out.

wiki suggests:
The mean daily intake from omnivore diets was determined to be around 58 mg (range from 9 to 372 mg) and to be low or negligible from a strict vegan diet. In another study, taurine intake was estimated to be generally less than 200 mg/day, even in individuals eating a high-meat diet. According to a third study, taurine consumption was estimated to vary between 40 and 400 mg/day.

this paper backs up the point:
Taurine is a major urinary amino acid in humans because the capacity of renal uptake is low. Daily taurine losses in urine are diet-dependent but generally range from 65 to 250 mg (0.5–2.0 mmoL).

if you do a google search, it would seem as though bioavailability of taurine is almost total, although i won't post a link for that.

the next thing to wonder is how much we create, and it would seem to be on the low end of what we're excreting:

The average daily synthesis in adults ranges between 0.4-1.0 mmol (50-125 mg)

so, we seem to urinate about as much as we create, and the more we eat, the more we eliminate on first pass.

the previous paper continues,

Plasma concentrations are maintained by a homeostatic control comprising a low renal tubular reabsorption threshold, relevant during periods of dietary restriction; unlike whole blood concentrations plasma concentrations vary rapidly in response to intake. Sturman et al. characterised taurine turnover by two exchangeable pools, a small (2.0 mmol or 0.25 g) and a large one (100 mmol or 12.5 g). The former is not a good indicator of individual tissue concentrations and most likely reflects dietary intake and urinary excretion, is rapidly miscible/exchangeable, with a half-life of 0.1 h; it includes bile, CNS and other tissues, most of which actively take up taurine against a concentration gradient. The large pool has a slow turnover rate and a half-life of 70 hours; it is yet unclear whether the large hepatic is readily available as a donor for other tissues, given its primary role on bile acid synthesis.

and, it concludes the thought:

The amount of taurine excreted daily varies from individual to individual, and in the same individual from day to day; it may reach 0.22-1.85 mmol and is influenced by various factors including genetics, age, sex, current dietary intake, renal function and clinical conditions. Patients with tubular dysfunction are at increased risk of deficiency. During periods of inadequate dietary intake or reduced availability of precursor amino acids, taurine renal reabsorption is increased favouring the maintenance of tissue stores. Conversely, high dietary intake and conditions inducing taurine release from cells, e.g. surgery, muscle disease/damage or radiation therapy, increase its renal excretion.

so, if you put that together, it would seem that 

(1) we absorb taurine almost totally
(2) we excrete it almost totally
(3) while very important to human metabolism, we seem to prefer the amount we create ourselves over the amount consumed in our diets, to the point that we'll even recycle it.

total metabolic requirements of taurine are consequently likely on the low side of those numbers - 60-100 mg - and more than that just gets excreted out on first pass.

this is lucky for me, then. as mentioned, it seems that i'm in the "low or negligible" category, based on this information, which zeros me out almost entirely:

specifically, there does not appear to be any taurine in eggs or milk at all - or, there is negligible amounts. so, i'm getting almost none of it from my diet at all.

strangely, though, if you sort around the internet, you may find a number of websites that suggest otherwise. this site, for example, actually shows up as a featured google site:

the data struck me as pretty clearly wrong, so i checked the source (the usda agricultural handbook #8) and it didn't even list taurine at all. so, i sent google some feedback asking them to remove the site from it's search results. it's misleading, at best.

that said, what the usda does measure is cysteine & methionine, the precursors your body needs to produce taurine, and the foods at that site listed - eggs, cheese, avocado, etc - are all high sources of these amino acids. so, if you eat a lot of eggs & cheese, you're at least giving your body the building blocks required to build it's own taurine, even if you're not ingesting it directly. and, i wonder if that's what that site meant to say and got confused about, and if there's a hint embedded within the error - that i should worry more about precursors. 

so, maybe i could potentially generate 1000 mg of taurine from 90 grams of cheese, under ideal conditions. certainly, my high cysteine intake suggests that there's reasons to be hopeful that i'm consuming enough amino acids, at the moment, to generate 60-100 mg of taurine fairly easily. but, it's not the question at hand.

so, what am i doing, then?

given that your body seems to prefer small dosages of this rather than large dosages of it, and it is actually fairly efficient at maintaining those small amounts while throwing away larger amounts, i'm going to treat this as fat soluble and come in at a round 100 mg for the rdi. so, i want to find a way to get to 30 mg per meal, with 120 mg total.

and, that might be difficult.

let's add it up.

nectarine - 0
banana -  0
strawberry - 0
avocado -  0
kiwi - 0
soy - >0
yeast - 0 <----fungi don't seem to provide it, either
cereal - 0
ice cream - 1.1*1.9  = 2.09  mg. 
flax seed - >0 
=======
<<30

red peppers - 0
cheese - 0
carrots - 0
hemp - >0
yogurt - 3.3*x ~ 5 mg
pasta - 0
yeast - 0
==================
<<30

eggs - 0
cheese - 0
bread - 0
yeast - 0
==================
<<30

coffee - 0
soy - > 0
=====================

as we can see, this isn't close to sufficient, but the more pressing concern is going to be regarding sources of cysteine and other amino acids, rather than sources of taurine.

so, there is no answer to this besides to eat actual meat, and i'm not willing to do that quite yet. however, i am willing to take note of the concern and make special care to ensure that any meat in my diet is chosen to maximize taurine intake, in the end.

i want to work out things like iron, first, to see.

so, i'll hang on to this for now, but i may delete it from the chart in the end.

i don't expect to hang on to b15, but let's see.

disclaimer:
i've gone to town with a few things - i'm not making up vitamins but rather filling things in. i mean, there's all these "missing vitamin names". what were they, exactly? it also gives me an excuse to work in a few things like choline that are hard to otherwise define as they are essential in some amount but not technically vitamins.

note that these numbers are scavenged and should be interpreted approximately. that's partly why i'm aiming to overshoot on most of it.

fruit bowl
(08:00)
pasta salad bowl
(00:00)
fried eggs
(16:00)
coffee
nec
tar
ine

1
129
g
ban
ana

1
136
g
str
awb
err
ies

5-6
150
g
avo
cdo

2*
75
g
kiwi
1
75
g
van
soy
milk

250
ml
che
rry
ice
crm

200
ml
nut
yst

1
med
tsp
3
g
frt
crl

55
g
grd
flax
seed

1
tbsp
7
g
sum red
pep
per
1
200
g
dur
um
wht
fet
55
g
+
h20
med
chd
chs
60
g
car
rot
1
110
g
hull
hemp
seed
1
tbsp
10 g
yog
urt
nut
yst
1
med
tsp
3
g
sum frd
egg
2*
70
g
med
chd
chs
30
g
marg
2
tsp
10
g
whl
wht
brd
w/
grm
+
flax
1 s
37
g
nut
yst
1
sml
tsp
2
g
jce
typ
grp
frt
250
ml
sum brw
cof
fee
700
ml
chc
soy
mlk
100
ml
sum total
raison
d'etre
b5,8 b5
b16
b5
b16
c
b3,4
b5,7
b8,9
f1,k
b5,8
c
k
a,d
b3,4
b5,7
b12
a
b5
b12
b13
b1,2
b3,4
b5,6
b7,9
b12
a,e
b3,5
b7,9
o-3
b16
b3,4
b9
c
b3,9 a
b12
b13
a
b3,9
b3
o-3
b13 b1,2
b3,4
b6,9
b12

a
b2,7
b12
a
b12
b13
d
o-3 b2,7
b12
c
caf
fei
ne

a
(fat sol)
(900 μg rae)
21.9
μg
4.08
μg
1.5
μg
10.5
μg
3
μg
10
%
13
%
0 15
%
0 42.5
r:38
c:4.5
314
μg
~
1.15
μg
30
%
918.5
μg
0 - 0 167
r:30
c:137
r:29
%
c:6.9
μg
15
%
10
%
0 0 - 55
r:54
c:1
0 4
%

4
r:4
c:0
268.5
r:126
c:142.5
b1
thiamin
(1.2 mg)
.044
mg
.042
mg
.036
mg
0.1
mg
.02025
mg
8
%
.0528
mg
~
155
%
20
%
.115
mg
217
u:34
.108
mg
~
46
%
.0174
mg
.0726
mg
.1275
mg
- ~
155
%
228
u:27
0.06
mg
.0087
mg
0 10.5
%
~
103
%
- 119
u: 5.5
0.1
mg
3
%
11
u:8
575
b2 [g, j]
riboflavin
(1.3 mg)
.035
mg
.099
mg
.033
mg
.195
mg
.01875
mg
25
%
.253
mg
~
144
%
24
%
.011
mg
242.5
u:49.5
.17
mg
~
22.5
%
.2568
mg
.0638
mg
.0285
mg
- ~
144
%
206.5
u:40
.684
mg
.1284
mg
0 3
%
~
96
%
- 161.5
u:62.5
.54
mg
10
%
51.5
u:41.5
662
b3
niacin
(16 mg)
1.45
mg
.904
mg
.579
mg
2.61
mg
.25575
mg
10
%
.1276
mg
~
65
%
36
%
.216
mg
149
n:38
f:111
1.958
mg
~
36
%
.0354
mg
1.0813
mg
0.92
mg
- ~
65
%
126
n:25
f:101
.114
mg
.0177
mg
0 6.5
%
~
43
%
- 50.5
n:1
f:49.5
1.36
mg
4
%
12.5
n:8.5
f:4
338
n:72.5
f:265
.5
b4*
adenine
(75 mg)
? 1.632
mg
0.75
mg
15.9
mg
~
.339
mg
19.25
mg
.9735
mg
49.38
mg
? ? 117.5 31.8
mg
2.2
mg
4.92
mg
0.77
mg
? - 49.38
mg
119 2.24
mg
2.46
mg
0 4.514
mg
32.92
mg
- 56
? 7.7
mg
10 302.5
b5
pantothenic
acid
(5 mg)
.239
mg
.454
mg
.1875
mg
2.08
mg
.13725
mg
15
%
.6391
mg
2.25
%
19
%
.069
mg
112
u:76
.634
mg
.23705
mg
.246
mg
.3003
mg
.056
mg
2.25
%
31
u:29
2.292
mg
0.123
mg
0 5
%
1.5
%
- 54.5
u:48
1.808
mg
6
%
42
u:36
239.5
b6
pyridoxine
(1.7 mg)
.032
mg
.499
mg
.0705
mg
.386
mg
.04725
mg
6
%
.0528
mg
~
133
%
25
%
.033
mg
230
u:66
.582
mg
.0781
mg
.0396
mg
.1518
mg
.06
mg

~
133
%
186.5
u:53.5
.255
mg
.0198
mg
0 3.5
%
~
88
%
- 107.5
u:16
~
0
2
%
2 526
b7 [h]
biotin
(35 μg)
? ~
3.212
μg
~
1.646
μg
5.4
μg
? ~
10.069
μg
2.86
μg
45
%
86
%
2.52
μg
204
u:73
6.6
μg
.22
μg
1.038
μg
5.5
μg
2.73
μg
- 45
%
91
u:46
~
58.33

μg
.519
μg
4.5474
μg
3
%
30
%
- 214
u:181
0 ~
11
%
11

520
b8*
inositol

(myo
or
lipid)
(1000 mg)
152.22
mg
0
mg
19.5
mg
69
mg
102
mg
20.09
mg
9.9
mg
14.85
mg
2.75
mg
13.65
mg
40 114
mg
~
41.23
mg
5.4
mg
13.2
mg
- 14.85
mg
19 12.6
mg
2.7
mg
~
16
mg
52.54
mg
9.9
mg
- 9 - - ~
0
68
b9
[m, b11, r]
folic acid
(400 μg dfe)
6.45
μg
27.2
μg
36
μg
122
μg
18.75
μg
n:6
f:0

%
5.5
μg

~
35.5
%
34
%
6.09
μg
131
n:61.5
f:69.5
92
μg
~
39
%
16.2
μg
20.9
μg
1.1
μg
- ~
35.5
%
107
n:32.5
f:74.5
70.5
μg
18.1
μg
0 5
%
~
23.5
%
- 48
n:24.5
f:23.5
3.5
%
2.5
%
6
n:6
f:0
292
n:124.5
f:167.5
b12 [t]
(cyano)
cobalamin
(2.4 μg) 
0 0 0 0 0 50
%
.858
μg
187.5
%
0 0 273
n:35.5
f:237.5
0 0 .66
μg
0 0 - 187.5
%
215
n:27.5
f:187.5
1.338
μg
.33
μg
0 0 125
%
- 194.5
n:69.5
f:125
0 20
%
20
n:0
f:20
702.5
n:132.5
f:570
b13*
orotic
acid
(10 mg)
- - - - - - ~
17
mg
- - - 170- - ~
37
mg
- - > - 370 - ~
18
mg
- - - - 180 - - - 720
b14*
taurine
(mg)
0 0 0 0 0 - 2.09
mg
0 0 - 6.5 0 0 0 0 - ~
5
mg
0 - 0 0 >0 0 0 0 - 0 >0 - -
b15*
pangamic
acid
- ~0 ~0 - ~0 0? ~0 - - - 0 - - - - - - - - - - - - - - - - - - -
b16*
choline
(fat sol)
(550 mg)
8
mg
4 1 4 1 11 5 1.5 1 1 29.5 2 2.5 2 1 - - 1.5 9 68 1 0 2 1.5 - 73.5 3 4.5 7.5 119.5
b20* [aka I]
l-carnitine
(25 mg)
- ~0 ~0 - ~0 ~0 5 - - - 5 - - - - - - - - - - - - - - - - - - -
c
(90 mg)
6.97 mg 34 74 25 117 4 0 0 25 ~0 279 350 0 0 7 0 - 0 357 0 0 0 0 0 100+ 0 0 0 736+
d
(fat sol)
(15 μg)
- 0 0 0 0 45 0 0 6 0 51 0 0 2 0 0 - 0 2 12 1 30 0 0 - 43 0 18 18 114
e
(fat sol)
(15 mg)
.993 2 1.5 16 10 0 2 0 36 0 67.5 13 1 1 2 7 - 0 24 9 .5 20 1.5 0 31 0 0 0 122.5
f1*
linoleic
acid
omega-6
(g)
(17 mg)
- .1086 .09 2.534 .187 1.5 .300 0 1.2 .414 6.3336 .0738 .540 .3462 .0828 2.87 - 0 3.9128 3.23 .1731 1.5 .5 0 - 5.4031 ~0 .8 .8 16.45
f2*
alpha
linolenic
acid
omega-3
(g)
(1.6 mg)
- .0638 .065 .165 .0319 .2 .200 0 .2 1.597 2.5227 .041 .024 .219 .0014 .93 - 0 1.2154 .228 .1095 .5 .75 0- 1.5875 ~0 .12 .12 5.45
f1:f2
ratio
- - - - - - - - - - 2.51- - - - - 2:1 - 3.22 - - - - - - 3.40 - - - 3.02
k
(fat sol)
(138 μg)
2.84 2 1 39 38 5 0 0 - - 85 10 1 1 12 0 - 0 24 9 .5 10 .5 0 - 20 0 2 2 131
q1*
coenzyme
q10 (mg)
(30 mg)
- .272 .075 - .0375 .625 .0308 - - - - - - - - - - - - - - - - - - - - - - -
q2*
pyrrolo
quinoline

 quinone
(mu-g)
- 3.536 - - 2.025 .063 .2101 - - - - - - - - - - - - - - - - - - - - - - -
s*
salicylic
acid
(mg)
- ~0 ~1 - ~
0.375
~0 ~0 - - - - - - - - - - - - - - - - - - - - - - -
- - - -- - - - - - - - - - - - - - - - - - - - - - - - - -

* not really.

complete requirements

fat soluble:
- a: 120% of pre-formed + 100% of convertible rae, total daily. 30% + pre-formed per meal.
- d: 30% + per meal, 120% total
- e: 30% + per meal, 120% total
- k: 30% + per meal, should not exceed 100%/meal, >120% & <200% total

water soluble (bs & c):
- 300+% total w/ 100% for each meal
- b1: 125% w/ each meal
- b2: 131% w/ each meal
- b3: 125% w/ each meal, but not more than 200% in fortified sources.
- *b4 (adenine): 75 mg w/ each meal
- b5: 110% w/ each meal
- b6: 118% w/ each meal
- b7: 171% w/ each meal, with 857% total as a goal.
- *b8 (inositol): 300 mg w/each meal, 1200 mg total
- b9: 100% w/each meal, but not more than 400% from fortified sources, per day.
- b12: 250% w/each meal, including 30+% pre-formed w/each meal. 120% pre-formed per day.
- *b13: 10 mg w/ each meal
- *b14 (taurine): 30 mg w/ each meal, 120 mg total
- *b16 (choline): 30% + per meal, 120% total

incomplete requirements legend:
>300% without meeting 100%/meal
+75<=100% each meal    [=+200%<=300% total]
+50<=75% each meal   [=+100<=200% total] 
<=50% each meal    [<100% total]

specific brands used:
- natura vanilla soy milk (light)
- chapman's black cherry ice cream
- bulk barn nutritional yeast
- vector cereal

- black diamond brand medium cheddar cheese
- selection brand pasta [metro/food basics]
- bulk barn nutritional yeast

- black diamond brand medium cheddar cheese
- irrestibles brand olive canola oil [metro/food basics]
- dempster's whole grain double flax bread
- bulk barn nutritional yeast

- natura chocolate soy milk
- no specific brand or type of coffee

diet options:

daily:

 2 ) pasta salad bowl:
- yogurt is high in b5 and b8 and b12 and choline.
- one tbsp of imitation bacon bits (isoflavones, maybe)
- lemon/lime (probably for phytonutrients) 
- garlic cloves (probably for phytonutrients)
- oregano & pepper (probably for phytonutrients)
- red clover (if locatable or foragable, for phytoestrogens)
- alfafa?
- sunflower seeds are high in b5 & high in e, with small amounts of choline but high amounts of omega-6. it doesn't really add up here, but may be better in the pasta bowl (after i work out the yogurt).
- rice bran is similar to sunflower in b5, but lower in omega-6 and lower in choline. also, less e. it would be better if i find myself strictly concerned about b5, but in the pasta bowl. this seems unlikely.
- dried whey is a little lower in both b5 & higher in choline, but also has a little b12 & has almost no fat. it's almost like the missing part of the yeast. i'm having trouble finding it though and don't think the isolate available at bulk barn is comparable. it seems to be largely seen as a waste product in yogurt production. it may be broadly useful across plates.

3) eggs:
- salami (45 g) (25% b1, 12% b3, 5% b5, 11.5% b6, 0% b9, 20% b12)
- rice (100 g) (60% b1, 35% b3, 4% b5, 6% b6, 69% b9)
- soy meat () <----only choice, really

- orange juice (1 cup) (15% b1, 4% b2, 5% b3, 5% b5, 5% b6, 19% b9, 207% c, added e?)
- grapefruit juice is high in inositol
- cranberry juice (unsweetened. need added c, has e)
- tomato juice

need: 6% b1, 75% b3, 45% b4, 65% b5, 15% b6, 25% b8, 55% b9, 60% b12, 10% k

==========

the list of everything i need to get.

added are green

13 vitamins:
1) A
2) B1 (thiamine)
3) B2 (riboflavin)
4) B3 (niacin)
5) B5 (pantothenic acid)
6) B6 (pyridoxine)

7) B7 (biotin)
8) B9 (folic acid)
9) B12 (cyano-cobolamin)
10)  C
11) D
12) E
13) K


15 amino acids:
1) histidine
2) isoleucine
3) leucine
4) lysine
5) methionine
6) phenylalanine
7) threonine
8) tryptophan
9) valine
10) arginine
11) cysteine
12) glycine
13) glutamine
14) proline
15) tyrosine
+ measure 6 non-essential

4 fatty acids:
1) linoleic acid
2) ala
3) dha
4) epa

23 minerals:
1) calcium
2) phosphorus
3) potassium
4) sulfur
5) sodium
6) chlorine
7) magnesium
8) iron
9) zinc
10) copper
11) manganese
12) iodine
13) selenium
14) molybdenum
15) chromium
16) fluoride
17) bromine
18) cobalt
19) tin
20) vanadium
21) silicon
22) boron
23) nickel
24) lead?

carotenoids (not including pro-vitamin a)
1) lutein
2) zeaxanthin
3) lycopene
4) phytofluene
5) phytoene
6) astaxanthin
7) capsanthin
8) canthaxanthin
9) cryptoxanthin

chlorophyll:
1) chlorophyll a
2) chlorophyll b

other molecules required for proper metabolic functions:
1) choline (cannot synthesize properly)
2) coQ10

3) lipoic acid
4) glutathione precursors
5) ergothioneine  (cannot synthesize)   <-----mushrooms
6) pyrroloquinoline quinone (PQQ) (cannot synthesize)   <-----kiwis
7) queuine  (cannot synthesize)    <-----cheese [made in stomach by bacteria]

8) taurine (cannot synthesize properly) <----cheese
9) betaine (more than a choline precursor?)
10) creatine? (avoidance? creatine increases muscle mass (which is bad.) but also improves brain function (which is good). careful.) 

glucose:
i'm more concerned about diabetes than weight gain, so...
the glycemic index is:
running total...

fiber:
i don't need many different types, i just need some. i'm not worrying about this.

& water

also, let's measure flavonoids:

anthocyanidins:
1) pelargonidin
2) delphinidin
3) cyanidin
4) malvinidin
5) peonidin
6) petunidin
7) rosinidin

flavonols:
1) isorhamnetin
2) kaempferol
3) myricetin
4) quercetin
5) fisetin
6) kaempferide

flavones:
1) luteolin
2) apigenin
3) techtochrysin
4) baicalein (to avoid!)
5) norwogonin
6) wogonin
7) nobiletin

flavanones:
1) eriodictyol
2) hesperetin
3) naringenin
4) hesperidin
5) isosakuranetin
6) pinocembrin
7) sterubin

isoflavones:
1) daidzein
2) genistein
3) glycitein
4) biochanin A
5) formononetin

i should try to measure some further phytoestrogens:
1) matairesinol
2) secoisolariciresinol
3) pinoresinol
4) lariciresinol
5) coumestrol

& finally, let's also measure:
1) saponins
2) ursolic acid (& precursors)
3) cafestol
4) resveratrol
5) ellagic acid
6) coumarin
7) tyrosol
8) hydroxytyrosol
9) oleocanthal
10) oleuropein
11) gingerol
12) phytic acid