i'm not getting good search results.

what i wonder is whether consistent mushroom consumption may actually flip the enzyme over. that is, i wonder if the way to digest mushrooms is to eat more mushrooms.

that said, the reason i'm not getting good results is that there seems to be some thinking that an inability to digest chitin is tied to lower levels of respiratory diseases, which is easy enough to understand, if you recognize that humans have a long history of living in crowded, unsanitary conditions. that is, the thought is that the mutation is linked to lower levels of respiratory illness because it better deactivates invading molds and whatnot, that enter your body as fungi spores from the air. the thought is that reversing the mutation might make us more susceptible to infection. it's at least a coherent explanation as to why we have this mutation and no other species does; we're the only species that lives in moldy huts.

if that's true - and it's not established that it is. - then we'd essentially be trading off the ability to digest mushrooms for a greater protection from air-borne fungus.

whether that is true or not, i would nonetheless call for some research into the question as to whether eating more mushrooms leads to greater expression or not. i mean, most of us eat almost no fungus (except dead yeast). so, if we don't eat any fungus, why do we need to create enzymes to digest it? we're better off protecting ourselves from air-borne spores. sure. but, can we undo it?

this article seems to suggest we can: 

https://www.researchgate.net/profile/Salvatore_Musumeci/publication/6249199_Human_Gastric_Juice_Contains_Chitinase_That_Can_Degrade_Chitin/links/00b4951a3972aba179000000/Human-Gastric-Juice-Contains-Chitinase-That-Can-Degrade-Chitin.pdf

....but it's not the focus of most research on this. the research dollars are about asthma.

so, i'd call on some more serious research, especially as we have more and more asians that eat more and more asian food - are they getting anything from this at all, or is it just fibre?

i'm going to make some eggs and get on the b6 after.

it seems, though, that this inability to digest chitin is something that humans are sort of unique in.

again: having a math degree means you can read anything and understand it instantly. it's like a "smarter than you" badge, even if employers think it's worthless.

so, i asked if it can crispr, and there's good evidence that it likely can - we seem to have lost this by accident, due to a bum mutation. mice can do it. orangutans can do it, too. so, all we need to do is find a way to flip the switch and turn the protein synthesis back on, and we'll be able to digest mushrooms again, like our recent ancestors could, in no time.

and, now the sneaky question - what about the epigenetics? 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5100053/

i'd rather we do this differently than prop up swashbuckling robber barons in the hydro or automotive sectors.

but, it has to get fucking done, and we're running out of time to do it in.

ontario & quebec, together, have been positioned to be the central engine of this transition process for decades, we've just had backwards looking petro-state governance for far too long. we should have been developing electricity as an export to cater to the electric vehicle market, not grasping on to collapsing columns in the oil industry.

again: i voted for these dumbasses for the very explicit reason that i was at least convinced they'd see the economic opportunity here, and then they disappointed the fuck out of me.

but, maybe they've come around. finally...

good.

now, lets get the hydro production back up, too - and start exporting it.

i mean, we should have done this 20 years ago, but it's better late than never.

https://www.thestar.com/politics/provincial/2020/10/08/doug-ford-teams-up-with-justin-trudeau-to-boost-electric-vehicle-production-in-ontario.html

it seems like the existing consensus is that the most reasonable path to eventual mushroom digestion is to develop a symbiosis with a new gut bacteria, rather than to edit our genome.

...even if editing our genome to digest mushrooms (and cellulose, while we're at it) sounds like so much fun. doesn't it?

see, this is why i'm not a fucking conservative, and you probably are.

that's how we got to being able to digest yeast (which is also a fungus), after all - we have bacteria in our gut that do it for us. 

so, how do i get me some mushroom digesting gut bacteria, then?

https://www.popsci.com/how-human-gut-bacteria-deal-fermented-foods/

apparently, the little bit of chitinase we produce is mostly as a self-defense mechanism against fungal infections (like yeast infections).

will it crispr?

what i'm actually wondering is if i can find an enzyme somewhere.

https://news.berkeley.edu/2018/05/16/what-we-inherited-from-our-bug-eating-ancestors/

so, with the eggs, the usda explicitly measured content in fried eggs. it measured raw eggs separately. and, while the numbers are roughly consistent [again: there's going to be error, here], it's leading me to the conclusion that it's measuring 46 g worth of cooked egg as a "large egg", rather than the result of cooking a 46 g raw egg. when you adjust for shell weight v the increased weight of fried v raw eggs, the fact that the fried egg comes in a little higher is likely a consequence of that difference. it also means that their large eggs are probably fairly small, and i'm seriously lowballing. i should probably weigh that more carefully when i get there. for now, i'll take the data at face value.

that said, if you want to get the most out of your eggs, you should cook them at low heat so you're not destroying the b vitamins.

the temperature where pantothenic acid becomes "highly unstable" is said, here, to be 120 degrees (celsius):

https://www.researchgate.net/publication/281276891_Thermal_degradation_kinetics_of_nicotinic_acid_pantothenic_acid_and_catechin_derived_from_Averrhoa_bilimbi_fruits

chitin requires very high temperature levels - 400 degrees celsius - to break down and release nutrients. frying it on your stove probably actually isn't even helping - that's as hot as a stove top gets, after lengthy pre-heating. 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4493705/

that's going to wipe out any b5.

mushrooms are useless. sorry.

and, i'm holding off on my election prediction for a reason.

the polling is relatively clear that biden is winning older white voters (many of them self-identified conservatives) by an increasingly large margin. that is likely to be decisive, in a fair election.

but, they don't have fair elections in the united states, and i have yet to form an opinion on the messaging i'm getting from the media. 

and, let's not be stupid, here.

aids ifr: 90%

coronavirus ifr: 0.2-0.3%

the comparison is an insult to every gay person that's ever been infected with aids, and anderson cooper should explicitly apologize for being a moron.

and, i need to reiterate that the premise that using antibodies to treat a virus is an "unproven" or "experimental" treatment is just absurdly scientifically illiterate. how do you think your body clears viruses, anyways? pixie dust?

prayer?

the issues trump has in front of him are twofold:

1) this is not a vaccine. so, there's no reason to think he's immune, despite what he said. i mean, maybe he got lucky - maybe his body mounted a proper immune response, meaning the antibody treatment wasn't required in the long run (although you're not going to clear this at his age in a weekend, indicating that the drugs were exceedingly effective). the fact that he was experiencing symptoms suggest his immune system at least reacted, but you won't know if he developed his own antibodies until the ones he was injected with wear off. and, i don't know the time frames involved with that. but, if he didn't develop his own antibodies then he's at risk of catching it again. and, you can imagine the headlines, with that one.

2) it's not entirely clear if they gave him enough to clear it altogether, and that's the only point where this is an experiment. if it got into one of his organs, for example, is the infusion going to root that out? it's the "missed" remnants that he needs to be concerned about, because when the injected antibodies wear off the virus will just get right back to it - if he didn't develop immunity in parallel.

so, is it a "cure"? i'd say yes. 

but, is it an antidote? no - it's hard to say for sure, but he's probably still vulnerable.

and, does it mean cooking your dietary animal liver - the only really substantive source there is - kills it, too?

hrmmn.

i know its heat sensitive. but, what temperature does it breakdown at?

so, does that mean my fried eggs don't really have much b5 in them, either?

the pasta isn't a major source, regardless.

let's see what information i can find about this.

to be clear - i get about 57 mg from 250 ml of soy.

so, it's more like 63 than 38. 

response from kelloggs on the choline:

One serving of Vector Meal Replacement contains 6 mg of choline per 1 ¼ cup (55 g) of Vector food, plus 32 mg of choline per ¾ cup (200 mL) of skim milk, for a total of 38 mg of choline.

of course, i'm consuming my cereal a little differently than that, but my estimate wasn't totally off - i had it around 2%, and it turns out it's closer to 1%.

so, that's been updated in the chart.

so, there's a catch with mushrooms.

in order to digest mushrooms, you have to break through the cell walls. this is generally done by cooking. but, guess what? b5 is destroyed by heat.

chopping might help a tad, but that's basically just chewing them.

so, if you want mushroom specifically for b5, you're probably out of luck, at any kind of reasonable serving size. 

now, in theory, cooking can sometimes make fat soluble vitamins more bioavailable. but, mushrooms are very low in fat soluble vitamins, so cooking them isn't going to do anything but destroy the nutrient content that does exist. the one counter-example is probably choline.

conclusion: mushrooms are a good source of an unusual type of fibre, and not much else.

just an update on the calories...

breakfast:

2*105 + 32*.75 + 240 + 61*.75 +  100 + 224 + 30*(3/2) + 217 + 9 = 1099.75

very late lunch:

90*3 + 130 + 70 + 100 + 30 + 200 = 800  (not including meat replacement)

very late supper::

2*26 + 318*(100/85) +2*130 + 41*1.1 + .1*553 + 30 = 816.5  (not including yogurt, mushrooms)

==============================

~2700

i'm ok with the breakfast being in the 1000+ calorie range, but i would like to bring the other two down closer to 500-750.

the eggs are not bad; the apple juice seems to be a little heavy, and i can probably improve on that.

for the pasta, i'm sure i'm going to take the pasta down to 75 or even 50, i just want to get the numbers in, first.

2*26 + .75*318*(100/85) +2*130 + 41*1.1 + .1*553 + 30 = 723

2*26 + .5*318*(100/85) +2*130 + 41*1.1 + .1*553 + 30 = 629.45

if, in the end, my numbers are:

breakfast: 1100

lunch: 750

supper: 650

================

2550

...then that's actually about what i want.

that said, in the end, i may cut it down to two meals by alternating the pasta & eggs dishes. i am having difficulty keeping up, and am about to scratch wednesday off the list and start fresh on thursday. that would put me back under 2,000 calories, and may be more sustainable; i may find it more "normal".

but, i'm more concerned about vitamin intake at the moment.

if, in the end, i'm convinced that i only need to eat twice rather than three times, i will.