i'm wary of the gentrification, but detroit is meandering towards something that amazon could help them get to faster. and, the cross-border integration would be an asset.
i get the idea that they want an atlantic port city, though.
the answer in strict terms is 'no', because of taxation headaches. but detroit or niagara are at least abstract possibilities.
http://www.cbc.ca/news/business/amazon-headquarters-canada-1.4297092