Saturday, September 12, 2020

so, to recall, here's where we're at

fruit bowl:
- strawberries
- bananas
- kiwis
- blueberries
- raspberries
- rosehips (if locatable)
- ice cream
- soy milk

salad bowl:
- red peppers
- tomatoes
- microwaved/chopped broccoli
- microwaved broccoli leaves or kale or dandelion leaves?
- chopped carrots
- hemp seeds (ground)
- flax seeds (ground!)
- kalamata olives
- lemon
- garlic cloves
- oregano & pepper
- chopped cheese
- bacon bits
- caesar dressing

eggs:
- fried eggs
- cheese
- whole wheat bread
- salami?
- indoor grown tuna or salmon?
- olive oil margarine
- + apple juice
In men, too much estrogen builds up in three common situations: obesity, excessive alcohol use, and smoking. This occurs because chronic inflammation, which is associated with these conditions, increases the conversion of testosterone into estrogen. Since estrogen causes the liver to produce more of the carrier protein for testosterone, which is known as sex hormone-binding globulin (SHBG), less free, or unbound, testosterone results. Low levels of free testosterone and higher estrogen levels in men are associated with excess body fat, reduced sex drive, depression, and erectile dysfunction. 

Since only free testosterone easily crosses into the brain, muscles and fat cells, much of the desirable action of testosterone has to do with the free portion. Free testosterone represents only a tiny amount of the total testosterone, equal to only 2 percent of the total in men and even less in women. 

DIM is able to support free testosterone without changing total testosterone levels; it does not raise testosterone levels but supports its activity through its effects on estrogen metabolism. This helps to maintain a healthy level of free, active testosterone. 

https://fortwaynephysicalmedicine.com/blog/the-benefits-of-dim

so, for me, that means kale is fine, too, especially if i can get my testicles removed, quickly; it may "liberate" free testosterone, but (1) i don't hardly have any of that, due to the t-blockers, (2) the concentration i'm getting from the food is very, very low and (3) it won't undo the effects of the t-blockers or stimulate more testosterone production.

good.

in the end, i'll probably pick one or the other depending on availability and price.

right now, i gotta eat to get around the idiot upstairs. and, i may pass out, again. fuck.
so, that disgusting old man is being disgusting again and i may have to get up to eat.

he also looks like he's gained about 100 pounds since the last time i saw him; when i moved in here, he would have been described as an aging jock, but now he's just fat and ugly. he's also grown a very unattractive amount of facial hair.

gotta love what that shit does to you.
ok, so what's my final take on the I3C-destroying-estrogen-fiasco?

1) i was going to microwave my broccoli anyways, because this article suggests that it increases the amount of vitamins e & a:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6049644/
2) according to this article, microwaving will remove most of the estrogen-destroying precursors:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722699/
3) this study, which is too vague to be useful, suggests that they initially didn't observe an increase in blood serum levels until they "adjusted" for it. they don't even indicate dosages. i think we may have found something pushed by the broccoli industry!
https://cebp.aacrjournals.org/content/9/8/773
4) going back to the original source,

i) there are ~ 30 mg of total glucosinolates in a half cup of chopped raw brocolli florets, which is about 40g
ii) <15% of that, 4.5 mg, is the precursor i'm worried about
iii) microwaving it should cut that by half, to around 2 mg
iv) there will be some loss in conversion to I3C
v) that itself needs to be converted to DIM
vi) so, i'm looking at, what? 1 mg? less?

Peak plasma concentration of DIM following ingestion of 400 mg I3C was 61 ng/mL

if we're looking at roughly linear changes in concentration, which is reasonable, then peak plasma concentration after 2 mg of consumption would be 0.3 ng/ml.

further, that appears likely to be cleared within an hour or two.

so, i'm clearing broccoli for minimal use...which i'm interested in for the a and the e and the not this stuff....

kale seems to have about twice as much as this stuff as broccoli, and if i don't need the extra vitamins, i may step back from it, except to ask what effect it has on testosterone. which is the next thing to figure out....

so, again: this chemical may be useful in fighting cancer if you take it as a supplement in high dosages (upwards of a gram/day), and if you're a transgendered person that finds themselves with a cancer caused by estrogen then you may be forced to detransition or die and this chemical is likely going to accelerate that detransition if you have to take it, but it doesn't appear to occur in food in sufficient dosages to worry about, or to have much of a cancer-fighting effect, either.
the magic number was around 200,000.

and here we are, in mid september - meaning there's what, six weeks before the election?

it's not going to stop tomorrow - people will keep dying for a long time. but, this is the turning point.

the united states, baffling as it may be, is likely nearing natural herd immunity.

https://www.worldometers.info/coronavirus/country/us/
the dauphin would not remember the dauphin experiment, aging as he may be, now.

https://www.bbc.com/worklife/article/20200624-canadas-forgotten-universal-basic-income-experiment
the federal liberals tried an experiment with the ubi in the 70s, but the results were never released. the open secret is that it worked a little too well.

the provincial liberals were experimenting with a ubi before they lost the 2018 election, and they seemed to be on the brink of adopting it. it's one of the first things that doug ford trashed when he took over.

the greens have had a ubi in their platform for years.

the ndp have generally opposed the policy, but have recently jumped on the bandwagon as a reaction to the pandemic.
you'll tell me a jobs guarantee is better because it reduces reliance.

reliance on what, exactly?

it's often presented as the more "socialist" position than a ubi, but when that argument is presented it generally tends to indicate that the person presenting it hasn't actually read any marx. i mean, i'll concede that a ubi is more like communism than it is like socialism, but socialists that reject communism are called reactionaries.

a jobs guarantee just makes workers reliant on capital; you end up giving people the choice between working and starving, forcing them into things they don't want to do (and it's the anarchist in me that hates that.) and holding them at the whim of whatever capital decides. moving to unions doesn't fix that.

so, what's worse - being reliant on the state or being reliant on capital? you pick your poison, but at least the state is marginally democratic.

the central argument produced by marx is that the socialization of production makes worker reliance unavoidable; we need a social contract between each other, because we can't avoid our reliance on each other anymore. arguing against reliance and in favour of total self-ownership is undoing history. it's an argument for the return of an agrarian society (and if we're going there anyway, let's dust of paine. you may be surprised to find out that...).

so, that's kind of a dumb argument.

and, i don't even think you have to choose - there's no contradiction between a ubi and a jobs guarantee, if you want one.

but, i'm an artist, i don't want one.
there is some non-zero chance that bay street may decide that a guaranteed basic income is the best way to stop street revolts and push it through.

it may crunch the numbers, and decide it's a more economical form of social welfare.

and, it may pick it up in the form of a negative income tax. that is the kind of party this is, when it's fully functioning, and at it's best.

but, recently, they just tend to ignore the convention, altogether - to their own detriment.

we'll see what happens.
you go to one of these conventions, and you think you're at a convention for a party that's a member of the socialist international; they're not "progressive" in the farmers-rights sense, they're often flat out socialist.

but, then you realize that the liberal party of canada is a member of the socialist international, and has historically been this country's worker's party, not the ndp. yet, they're also the bankers party - and the bankers tend to win, and direct policy. it's very weird.

it's a "natural governing party" in a very real sense.
the liberal party and it's members are two very different groups of people. the conventions are always very, very far to the left of what actually happens, when they govern.

it's fun to attack the liberals as campaigning on the left and governing on the right, but the truth is that that's as much of an observation on the disconnect between the party and it's members as it is anything else.

if history is any guide, they will pass a resolution and the prime minister will act like it never happened.

but, these conventions also define the discourse, so let's hope they ramp it up.

https://www.cbc.ca/news/politics/guaranteed-basic-income-priorities-liberals-1.5721943
can we save brocolli?

an increase of 10 g of broccoli was associated with an increase of 0.01 (95% CI, −0.09 to 0.11) in 2:16 values.

so, they couldn't measure the effects of indole-3-carbinol much.

i need a nap. but i think i can save the broccoli and kale, too - supplements seem to demonstrate some effect, but there's not enough absorption to make a difference.
that's not the answer i want, it doesn't seem.

farmed trout has about the same ratio as brocolli or kale, it's just more concentrated. i'm not getting anywhere with that.

what i need is something like this, and i'll keep an eye out for it:
http://www.kuterra.com/
http://www.littlecedarfalls.com/steelhead-salmon.html
https://sustainableblue.com/

tuna is actually even better, for what i want it for, but it doesn't seem to be happening indoors at all, at this point.

we'll see what the numbers look like, when i add them up.
what i want is, like, an inland growing pond, not putting them in a cage on the shore.

i wouldn't expect any serious difference in mercury concentrations, if all you're doing is putting a cage around them. you have to take them out of the ocean, for that, altogether...

so, i guess i want freshwater farmed fish, to start.
ugh.

i need some fish.

it must be farmed.
if the flax at least won't convert the circulating 16 into 2 once it's been metabolized from estrone, how do i get more estrogenic 16-isomers?

this article suggests that it's the omega-6 that converts estrone to 16-isomers and the omega-3 that converts estrone to 2-isomers. that suggests that the reason the flax increased 2-isomer production may be that it's high in omega-3s. it also suggests that, ultimately, the cancer risk is tied into the omega-3:omega-6 ratio, rather than any specific component of the diet.

like everybody else, i have a positive 6:3 ratio because it's just how we eat. you'd essentially have to eat primarily seafood, and accept the risk of the mercury content, to get around that.

so, i need to be careful - on the one hand, i want sufficient 6s to overpower the 2s to feminize, but, on the other hand, i want low total fat to keep the testosterone down and prevent a cancer risk.

i seem to be doing that right as it is.

https://www.baritzwellness.com/storage/app/media/estrogen-metabolism.pdf
this is what i want - a randomized study with a sufficient sample size for post-menopausal women:
https://www.tandfonline.com/doi/full/10.1080/01635581.2018.1516789

it took me some time to understand it, though.

this is the takeaway: there were statistically relevant increases of the 2-isomer and of the 2:16 isomer ratio, without any statistically relevant effect on the 16. there were not statistically relevant effects on any other estrogens, but there was a slight decrease in prolactin. so, the 2 went up and the 16 stayed steady, and everything else stayed steady, too, except the prolactin. that means that it is not the case that the 16 was converted into 2 - it is the case that the female body increased production of the 2-isomer. their concern is cancer, so they very specifically want less 16 and more 2. so, from their perspective, the trial failed to convert the 16 into the 2.

but, this article here explains that the 16 is more feminizing than the 2:
https://www.sciencedirect.com/topics/medicine-and-dentistry/2-methoxyestrone

that means i actually don't want that conversion to happen, and am happy it was not observed.

further, to be clear:

Flaxseed intake did not significantly influence circulating levels of estradiol, free estradiol, estrone, or estrone sulfate in our study. This is consistent with other intervention studies assessing serum (32,35,36), plasma (37), or urinary (33) estrogen levels in postmenopausal women, with the exception of a crossover trial reporting statistically significant reductions in serum estradiol and estrone sulfate with 10 g flaxseed/day for 7 weeks (34). The most biologically active estrogens, estradiol, and estrone, have been associated with elevated postmenopausal breast cancer risk (18,19), thus factors decreasing their levels may be protective. In vitro studies have suggested that lignans may decrease estrogen synthesis by inhibiting the aromatase enzyme responsible for converting testosterone and androstenedione to estradiol and estrone, respectively (28,29,60). However, evidence from intervention trials, including ours, provides stronger support for flaxseed’s role in modifying estrogen metabolism (e.g., 2-hydroxylation of estrone) rather than inhibiting estrogen synthesis.

so, it seems like what they're suggesting is that i shouldn't expect the lignans in flaxseed to have any effect on estrogen circulating in my bloodstream at all, and that is at least a start - do no harm. the decrease in prolactin is also fine, as i produce some as a byproduct of the testosterone suppression.

then, if i wouldn't expect an effect on circulating estrogens, might flaxseed help to suppress testosterone production in genetic men?

apparently, yes - flax consumption, in conjunction with low total fat, should cut down testosterone production by more than a half:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703189/

so, we're adding some flax :)
wait.

does flax increase or decrease estrogen levels?

obviously, i don't want to take anything that might decrease it.

so, that's my immediate task - to determine whether flax & broccoli, at dietary levels, are actually estrogen blockers. if they are, no thank you. if they're not, i can move forward with them.

google searches are throwing back contradictory answers.
and, i just learned that you can digest flax, if you ground it first.

i mentioned somewhere back there - a couple of times - that flax seeds are a total waste of time, because they're just fibre.

but, i didn't realize that you could fix that if you grind them. that's good news, as they should more or less perfectly balance out the hemp seeds.

so, this is where i'm at so far.

fruit bowl:
- strawberries
- bananas
- kiwis
- blueberries
- raspberries
- rosehips (if locatable)
- ice cream
- soy milk

salad bowl:
- red peppers
- tomatoes
- microwaved/chopped broccoli
- broccoli leaves or kale
- dandelion leaves
- chopped carrots
- hemp seeds
- flax seeds (ground!)
- kalamata olives
- lemon
- garlic cloves
- oregano & pepper
- chopped cheese
- bacon bits
- caesar dressing

eggs:
- fried eggs
- cheese
- whole wheat bread
- salami?
- olive oil margarine
- + apple juice
ok...

that chemical seems to be poorly absorbed. still, it's something to be very wary of. maybe i might want to find away around that, in getting vitamins e and a. that's a major strike against both broccoli and kale, and "cruciferous vegetables", which i've long viewed as overrated but was finally coming around to, in general.

if i don't need them, maybe i shouldn't bother.

so, this is where i'm at so far.

fruit bowl:
- strawberries
- bananas
- kiwis
- blueberries
- raspberries
- rosehips (if locatable)
- ice cream
- soy milk

salad bowl:
- red peppers
- tomatoes
- microwaved/chopped broccoli
- broccoli leaves or kale
- chopped carrots
- hemp seeds
- kalamata olives
- lemon
- garlic cloves
- oregano & pepper
- chopped cheese
- bacon bits
- caesar dressing

eggs:
- fried eggs
- cheese
- whole wheat bread
- salami?
- olive oil margarine
- + apple juice
and, then i read this, which is freaking me out about both broccoli and kale...

https://lpi.oregonstate.edu/mic/dietary-factors/phytochemicals/indole-3-carbinol

seems like i might want to avoid those?

more research required, clearly.