A) TOXICITY: A minimum toxic dose has not been established.
1) After ingesting 11,000 mg of niacin within a 12-hour
period, a 56-year-old man developed severe, persistent
hypotension (BP 58/40 mmHg) in the absence of cutaneous
flushing. Following supportive therapy, he recovered
completely.
2) A 16-year-old girl developed epigastric discomfort and
rash after taking 330 mg of niacin daily (more than 25
times the recommended daily allowance for a teenager).
Symptoms resolved upon discontinuation of therapy.
3) Two teenagers developed hepatotoxicity and acidosis
after ingestion of 5 and 6 g of sustained-release niacin
over a 48-hour period.
i think that what is more concerning to me is that b3 is often used to reduce bad cholesterol, and my bad cholesterol is already kind of dangerously low. i know: this isn't even a first world problem, because the first world is so overwhelmingly obese. but, if i shut my ldl off altogether, i will literally melt into a puddle of goop in front of you. we need cell membranes.
while we're on this topic, when are we going to bioengineer ourselves a proper fucking cell wall, anyways? that's a wall i'd enslave a million mexicans for. no, this is typical - the republicans are always decades behind the curve.
i want a cell wall, dammit.
and, i want to photosynthesize, too. how's that for a plan to abolish capitalism? fuck your wage slavery - i have chloroplasts, now. you're fucked. freedom is inevitable.
anyways.
if i take it, i'll take it at reasonable doses with the intent of giving my cells a bit of a boost and not as a fiend trying to chase immortality and take myself back thirty years. but, it's nice to know that even 11 g of the shit probably won't kill you.
there's a suggested adult dose at the bottom:
Initial: 500 mg orally once daily at bedtime for 4 weeks,
then 1000 mg at bedtime for 4 weeks; titrate by
tolerability and efficacy but no faster than 500 mg every
4 weeks; usual maintenance dose, 1000 to 2000 mg once
daily at bedtime; MAX 2000 mg/day.
if there's a bottle at the store for a reasonable price, i'll probably grab it. what's the worst thing that could happen?
https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+1237