Tuesday, March 28, 2017

A)  TOXICITY: A minimum toxic dose has not been established.
    1)  After ingesting 11,000 mg of niacin within a 12-hour
        period, a 56-year-old man developed severe, persistent
        hypotension (BP 58/40 mmHg) in the absence of cutaneous
        flushing. Following supportive therapy, he recovered
        completely.
    2)  A 16-year-old girl developed epigastric discomfort and
        rash after taking 330 mg of niacin daily (more than 25
        times the recommended daily allowance for a teenager).
        Symptoms resolved upon discontinuation of therapy.
    3)  Two teenagers developed hepatotoxicity and acidosis
        after ingestion of 5 and 6 g of sustained-release niacin
        over a 48-hour period.
 
i think that what is more concerning to me is that b3 is often used to reduce bad cholesterol, and my bad cholesterol is already kind of dangerously low. i know: this isn't even a first world problem, because the first world is so overwhelmingly obese. but, if i shut my ldl off altogether, i will literally melt into a puddle of goop in front of you. we need cell membranes.

while we're on this topic, when are we going to bioengineer ourselves a proper fucking cell wall, anyways? that's a wall i'd enslave a million mexicans for. no, this is typical - the republicans are always decades behind the curve.

i want a cell wall, dammit.

and, i want to photosynthesize, too. how's that for a plan to abolish capitalism? fuck your wage slavery - i have chloroplasts, now. you're fucked. freedom is inevitable.

anyways.

if i take it, i'll take it at reasonable doses with the intent of giving my cells a bit of a boost and not as a fiend trying to chase immortality and take myself back thirty years. but, it's nice to know that even 11 g of the shit probably won't kill you.

there's a suggested adult dose at the bottom:

 Initial: 500 mg orally once daily at bedtime for 4 weeks,
       then 1000 mg at bedtime for 4 weeks; titrate by
       tolerability and efficacy but no faster than 500 mg every
       4 weeks; usual maintenance dose, 1000 to 2000 mg once
       daily at bedtime; MAX 2000 mg/day. 
 
if there's a bottle at the store for a reasonable price, i'll probably grab it. what's the worst thing that could happen?

https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+1237